PittsburghV1, Main, Exploration, bibRecord, 001E19

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Identifieur interne : 001E19 ( Main/Exploration ); précédent : 001E18; suivant : 001E20

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Auteurs : Susan E. Steck ; Lesley M. Butler ; Temitope Keku ; Samuel Antwi ; Joseph Galanko [États-Unis] ; Robert S. Sandler [États-Unis] ; Jennifer J. Hu

Source :

Mutation research [ 0027-5107 ] ; 2014.

RBID : PMC:4056032

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Adénocarcinome (), Adénocarcinome (ethnologie), Adénocarcinome (génétique), Afro-Américains, Animaux, Benzopyrènes (administration et posologie), Bovins, Cancérogènes (administration et posologie), Caroline du Nord, Composés hétérocycliques (administration et posologie), Cuisine (préparation), Enquêtes et questionnaires, Femelle, Génotype, Humains, Mâle, Odds ratio, Polymorphisme de nucléotide simple, Population d'origine européenne, Protéines de liaison à l'ADN (génétique), Risque, Réparation de l'ADN, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du côlon (), Tumeurs du côlon (ethnologie), Tumeurs du côlon (génétique), Viande (effets indésirables).
MESH :
- administration et posologie : Benzopyrènes, Cancérogènes, Composés hétérocycliques.
- effets indésirables : Viande.
- ethnologie : Adénocarcinome, Tumeurs du côlon.
- génétique : Adénocarcinome, Protéines de liaison à l'ADN, Tumeurs du côlon.
- Adulte, Adulte d'âge moyen, Adénocarcinome, Afro-Américains, Animaux, Bovins, Caroline du Nord, Cuisine (préparation), Enquêtes et questionnaires, Femelle, Génotype, Humains, Mâle, Odds ratio, Polymorphisme de nucléotide simple, Population d'origine européenne, Risque, Réparation de l'ADN, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du côlon.

English descriptors

KwdEn :
- Adenocarcinoma (chemically induced), Adenocarcinoma (ethnology), Adenocarcinoma (genetics), Adult, African Americans, Aged, Aged, 80 and over, Animals, Benzopyrenes (administration & dosage), Carcinogens (administration & dosage), Cattle, Colonic Neoplasms (chemically induced), Colonic Neoplasms (ethnology), Colonic Neoplasms (genetics), Cooking, DNA Repair, DNA-Binding Proteins (genetics), European Continental Ancestry Group, Female, Genotype, Heterocyclic Compounds (administration & dosage), Humans, Male, Meat (adverse effects), Middle Aged, North Carolina, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Surveys and Questionnaires.
MESH :
- chemical , administration & dosage : Benzopyrenes, Carcinogens, Heterocyclic Compounds.
- geographic : North Carolina.
- adverse effects : Meat.
- chemically induced : Adenocarcinoma, Colonic Neoplasms.
- ethnology : Adenocarcinoma, Colonic Neoplasms.
- genetics : Adenocarcinoma, Colonic Neoplasms, DNA-Binding Proteins.
- Adult, African Americans, Aged, Aged, 80 and over, Animals, Cattle, Cooking, DNA Repair, European Continental Ancestry Group, Female, Genotype, Humans, Male, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Surveys and Questionnaires.

Abstract

Purpose

Much of the DNA damage from colon cancer-related carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) from red meat cooked at high temperature, are repaired by the nucleotide excision repair (NER) pathway. Thus, we examined whether NER non-synonymous single nucleotide polymorphisms (nsSNPs) modified the association between red meat intake and colon cancer risk.

Methods

The study consists of 244 African-American and 311 white colon cancer cases and population-based controls (331 African Americans and 544 whites) recruited from 33 counties in North Carolina from 1996 to 2000. Information collected by food frequency questionnaire on meat intake and preparation methods were used to estimate HCA and benzo(a)pyrene (BaP, a PAH) intake. We tested 7 nsSNPs in 5 NER genes: XPC A499V and K939Q, XPD D312N and K751Q, XPF R415Q, XPG D1104H, and RAD23B A249V. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression.

Results

Among African Americans, we observed a statistically significant positive association between colon cancer risk and XPC 499 AV+VV genotype (OR=1.7, 95% CI: 1.1, 2.7, AA as referent), and an inverse association with XPC 939 QQ (OR=0.3, 95%CI: 0.2, 0.8, KK as referent). These associations were not observed among whites. For both races combined, there was interaction between the XPC 939 genotype, well-done red meat intake and colon cancer risk (OR=1.5, 95% CI=1.0, 2.2 for high well-done red meat and KK genotype as compared to low well-done red meat and KK genotype, p_interaction =0.05).

Conclusions

Our data suggest that NER nsSNPs are associated with colon cancer risk and may modify the association between well-done red meat intake and colon cancer risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056032

DOI: 10.1016/j.mrfmmm.2014.02.004
PubMed: 24607854
PubMed Central: 4056032

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (chemically induced)</term>
<term>Adenocarcinoma (ethnology)</term>
<term>Adenocarcinoma (genetics)</term>
<term>Adult</term>
<term>African Americans</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Benzopyrenes (administration & dosage)</term>
<term>Carcinogens (administration & dosage)</term>
<term>Cattle</term>
<term>Colonic Neoplasms (chemically induced)</term>
<term>Colonic Neoplasms (ethnology)</term>
<term>Colonic Neoplasms (genetics)</term>
<term>Cooking</term>
<term>DNA Repair</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>European Continental Ancestry Group</term>
<term>Female</term>
<term>Genotype</term>
<term>Heterocyclic Compounds (administration & dosage)</term>
<term>Humans</term>
<term>Male</term>
<term>Meat (adverse effects)</term>
<term>Middle Aged</term>
<term>North Carolina</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome ()</term>
<term>Adénocarcinome (ethnologie)</term>
<term>Adénocarcinome (génétique)</term>
<term>Afro-Américains</term>
<term>Animaux</term>
<term>Benzopyrènes (administration et posologie)</term>
<term>Bovins</term>
<term>Cancérogènes (administration et posologie)</term>
<term>Caroline du Nord</term>
<term>Composés hétérocycliques (administration et posologie)</term>
<term>Cuisine (préparation)</term>
<term>Enquêtes et questionnaires</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Risque</term>
<term>Réparation de l'ADN</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du côlon ()</term>
<term>Tumeurs du côlon (ethnologie)</term>
<term>Tumeurs du côlon (génétique)</term>
<term>Viande (effets indésirables)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Benzopyrenes</term>
<term>Carcinogens</term>
<term>Heterocyclic Compounds</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>North Carolina</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Benzopyrènes</term>
<term>Cancérogènes</term>
<term>Composés hétérocycliques</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Meat</term>
</keywords>
<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colonic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Viande</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Adénocarcinome</term>
<term>Tumeurs du côlon</term>
</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colonic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma</term>
<term>Colonic Neoplasms</term>
<term>DNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adénocarcinome</term>
<term>Protéines de liaison à l'ADN</term>
<term>Tumeurs du côlon</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>African Americans</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Animals</term>
<term>Cattle</term>
<term>Cooking</term>
<term>DNA Repair</term>
<term>European Continental Ancestry Group</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
<term>Surveys and Questionnaires</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Adénocarcinome</term>
<term>Afro-Américains</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Caroline du Nord</term>
<term>Cuisine (préparation)</term>
<term>Enquêtes et questionnaires</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Odds ratio</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne</term>
<term>Risque</term>
<term>Réparation de l'ADN</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tumeurs du côlon</term>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">Much of the DNA damage from colon cancer-related carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) from red meat cooked at high temperature, are repaired by the nucleotide excision repair (NER) pathway. Thus, we examined whether NER non-synonymous single nucleotide polymorphisms (nsSNPs) modified the association between red meat intake and colon cancer risk.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">The study consists of 244 African-American and 311 white colon cancer cases and population-based controls (331 African Americans and 544 whites) recruited from 33 counties in North Carolina from 1996 to 2000. Information collected by food frequency questionnaire on meat intake and preparation methods were used to estimate HCA and benzo(a)pyrene (BaP, a PAH) intake. We tested 7 nsSNPs in 5 NER genes: <italic>XPC A499V</italic>
 and <italic>K939Q</italic>
, <italic>XPD D312N</italic>
 and <italic>K751Q, XPF R415Q</italic>
, <italic>XPG D1104H</italic>
, and <italic>RAD23B A249V</italic>
. Adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among African Americans, we observed a statistically significant positive association between colon cancer risk and <italic>XPC 499 AV+VV</italic>
 genotype (OR=1.7, 95% CI: 1.1, 2.7, <italic>AA</italic>
 as referent), and an inverse association with <italic>XPC 939 QQ</italic>
 (OR=0.3, 95%CI: 0.2, 0.8, <italic>KK</italic>
 as referent). These associations were not observed among whites. For both races combined, there was interaction between the <italic>XPC 939</italic>
 genotype, well-done red meat intake and colon cancer risk (OR=1.5, 95% CI=1.0, 2.2 for high well-done red meat and <italic>KK</italic>
 genotype as compared to low well-done red meat and <italic>KK</italic>
 genotype, p<sub><italic>interaction</italic>
</sub>
 =0.05).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Our data suggest that NER nsSNPs are associated with colon cancer risk and may modify the association between well-done red meat intake and colon cancer risk.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
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<region><li>Caroline du Nord</li>
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</settlement>
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<tree><noCountry><name sortKey="Antwi, Samuel" sort="Antwi, Samuel" uniqKey="Antwi S" first="Samuel" last="Antwi">Samuel Antwi</name>
<name sortKey="Butler, Lesley M" sort="Butler, Lesley M" uniqKey="Butler L" first="Lesley M." last="Butler">Lesley M. Butler</name>
<name sortKey="Hu, Jennifer J" sort="Hu, Jennifer J" uniqKey="Hu J" first="Jennifer J." last="Hu">Jennifer J. Hu</name>
<name sortKey="Keku, Temitope" sort="Keku, Temitope" uniqKey="Keku T" first="Temitope" last="Keku">Temitope Keku</name>
<name sortKey="Steck, Susan E" sort="Steck, Susan E" uniqKey="Steck S" first="Susan E." last="Steck">Susan E. Steck</name>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Galanko, Joseph" sort="Galanko, Joseph" uniqKey="Galanko J" first="Joseph" last="Galanko">Joseph Galanko</name>
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<name sortKey="Sandler, Robert S" sort="Sandler, Robert S" uniqKey="Sandler R" first="Robert S." last="Sandler">Robert S. Sandler</name>
</country>
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</record>

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EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001E19 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001E19 | SxmlIndent | more

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{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4056032
   |texte=   Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24607854" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

Nucleotide Excision Repair Gene Polymorphisms, Meat Intake and Colon Cancer Risk

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English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.